The Drexler-Colombo Building is in the Jackson Square Historic District.

Other individually designated landmarks in this historic district are:

• Bank of Lucas, Turner and Company
• Belli Building
• Columbus Savings Bank
• First Jewish Religious Services
• Freemasons Site
• Fugazi Bank Building
• Genella Building
• Ghirardelli Building
• Ghirardelli Annex
• Golden Era Building
• Grogan-Lent-Atherton Building
• Hotaling Building
• Hotaling Annex East
• Hotaling Annex West
• Hotaling Stables
• Medico-Dental Building
• Mouline Building
• Old Ohio Street Houses
• Solari Building East
• Solari Building West
• Yeon Building